Selected Publications

Goodarzi H, Nguyen HCB, Zhang S, Dill BD, Molina H, Tavazoie SF. Modulated expression of specific tRNAs drives gene expression and cancer progression. Cell. 2016 Jun 2;165(6):1416-27. doi: 10.1016/j.cell.2016.05.046.

Nguyen A, Yoshida M, Goodarzi H, Tavazoie SF*. Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness. Nat Commun. 2016 May 3;7:11246. doi: 10.1038/ncomms11246.

Halberg N.*, Sangelaub C.A., Navrazhina K., Molina H., Uryu K., and Tavazoie S.F.* PITPNC1 recruits RAB1B to the Golgi Network to Drive Malignant Secretion. Cancer Cell. 2016 Mar 14; 29(3):339-53. Doi: 10.1016/j.ccell.2016.02.013.

Fish L, Pencheva N, Goodarzi H, Tran H, Yoshida M, Tavazoie SF*. Muscleblind-like 1 suppresses breast cancer metastatic colonization and stabilizes metastasis suppressor transcripts. Genes Dev. 2016 Feb 15;30(4):386-98. doi: 10.1101/gad.270645.115.

Nguyen A, Loo JM, Mital R, Weinberg EM, Man FY, Zeng Z, Paty PB, Saltz L, Janjigian YY, de Stanchina E, Tavazoie SF.* PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis.  J Clin Invest. 2016 Feb 1;126(2):681-94. Doi: 10.1172/JCI83587.

Sengelaub CA, Navrazhina K, Ross JB, Halberg N, Tavazoie SF.* PTPRN2 and PLCB1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling. EMBO J. 2016 Jan 4;35(1):62-76. doi: 10.15252/embj.201591973.

Alarcón CR, Goodarzi H, Lee H, Liu X, Tavazoie S, Tavazoie S.F.* NRNPA2B1 is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events. Cell. 2015 Sep 10;162(6):1299-308. doi: 10.1016/j.cell.2015.08.011.

Goodarzi H., Liu X., Nguyen H.C.B., Zhang S., Fish L., and Tavazoie S.F.* Endogenous tRNA-derived fragments suppress breast cancer progression through transcript displacement. Cell 2015 May 7;161(4):790-802. doi: 10.1016/j.cell.2015.02.053.

Furlow P.W., Zhang S., Soong T.D., Halberg N., Goodarzi H., Mangrum C., Wu G.Y., Elemento O., and Tavazoie S.F.* Mechanosensitive pannexin-1 channels mediate metastatic cell survival in the microvasculature.  Nature Cell Biology 2015 May;17(5):651-64. doi: 10.1038/ncb3148

Alarcon C., Lee H.L., Goodarzi H., and Tavazoie S.F.* N6-methyladenosine marks primary microRNAs for processing. Nature 2015 Mar 26;519(7544):482-5. doi: 10.1038/nature14281

Ross J.B., Huh D., Noble L.B., and Tavazoie S.F.* Identification of molecular determinants of primary and metastatic tumor re-initiation in breast cancer. Nature Cell Biology  2015 May;17(5):651-64. doi: 10.1038/ncb3148.

Loo J., Scherl A., Nguyen A., Man F.Y., Zeng Z., Saltz L., Paty P.B., and Tavazoie S.F.* Extracellular metabolic energetics drive colorectal cancer progression. Cell, 2015 January 29; 160(3):393-406. doi:10.1016/j.cell.2014.12.018

Goodarzi H., Zhang S., Buss C.G., Fish L., Tavazoie S. and Tavazoie S.F. Metastasis-suppressor transcript destabilization by an RNA-binding protein that binds mRNA hairpins. Nature, 2014 July 9; doi:10.1038 / nature13466.

Pencheva N., Buss C., Posada J., Merghoub T.,  and Tavazoie S.F. Broad-Spectrum Therapeutic Suppression of Metastatic Melanoma Through Nuclear Hormone Receptor Activation. Cell  2014 Feb 27;156(5):986-1001 

Pencheva N., and Tavazoie S.F. Control of metastatic progression by microRNA regulatory network Nature Cell Biology 2013 Jun;15(6):546-54

Pencheva N., Tran H., Buss C., Huh D., Drobnjak M., Busam K., and Tavazoie S.F. Convergent multi-miRNA Targeting of ApoE Drives LRP1/LRP8-Dependent Melanoma Metastasis and Angiogenesis. Cell  2012 Nov 21;151(5):1068-82

Png KJ, Halberg N, Yoshida M, Tavazoie SF.  A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells.  PMID 22170610   Nature 2012 JAN 12;481(7380):190-194,96-97

Png K.J., Yoshida M., Zhang X.H.-F., Shu W., Lee H., Rimner A., Chan T.A., Comen E., Andrade V.P., Kim S.W., King T.A., Hudis C.A., Norton L., Hicks J., Massagué J., Tavazoie S.F.  MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes & Development, 2011 25:226-231

Tavazoie SF , Alarcon C , Oskarsson T , Padua D , Wang Q , Bos PD , Gerald WL , Massague J   Endogenous human microRNAs that suppress breast cancer metastasis. PMID: 18185580   Nature 2008 JAN 451(7175):147-52