Tavazoie Lab
Mei W, Faraj Tabrizi S, Godina C, Lovisa AF, Isaksson K, Jernström H, Tavazoie SF. A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor. Cell. 2024 Dec 9:S0092-8674(24)01326-6. doi: 10.1016/j.cell.2024.11.009. Epub ahead of print. PMID: 39657676.
Padmanaban V, Keller I, Seltzer ES, Ostendorf BN, Kerner Z, Tavazoie SF. Neuronal substance P drives metastasis through an extracellular RNA-TLR7 axis. Nature. 2024 Sep;633(8028):207-215. doi: 10.1038/s41586-024-07767-5. Epub 2024 Aug 7. PMID: 39112700; PMCID: PMC11633843.
Yamaguchi N, Wu YG, Ravetch E, Takahashi M, Khan AG, Hayashi A, Mei W, Hsu D, Umeda S, de Stanchina E, Lorenz IC, Iacobuzio-Donahue CA, Tavazoie SF. A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention. Cancer Discov. 2024 Dec 2;14(12):2489-2508. doi: 10.1158/2159-8290.CD-23-1323. PMID: 39028915; PMCID: PMC11611693.
Millet A, Ledo JH, Tavazoie SF. An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer's brains. Immunity. 2024 Jan 9;57(1):153-170.e6. doi: 10.1016/j.immuni.2023.12.001. Epub 2023 Dec 29. PMID: 38159571; PMCID: PMC10805152.
Hsu DJ, Gao J, Yamaguchi N, Pinzaru A, Wu Q, Mandayam N, Liberti M, Heissel S, Alwaseem H, Tavazoie S, Tavazoie SF. Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells. Sci Adv. 2023 Jan 6;9(1):eade9120. doi: 10.1126/sciadv.ade9120. Epub 2023 Jan 6. PMID: 36608131; PMCID: PMC9821863.
Earnest-Noble LB, Hsu D, Chen S, Asgharian H, Nandan M, Passarelli MC, Goodarzi H, Tavazoie SF. Two isoleucyl tRNAs that decode synonymous codons divergently regulate breast cancer metastatic growth by controlling translation of proliferation-regulating genes. Nat Cancer. 2022 Dec;3(12):1484-1497. doi: 10.1038/s43018-022-00469-9. Epub 2022 Dec 12. PMID: 36510010; PMCID: PMC11323107.
Ostendorf BN, Patel MA, Bilanovic J, Hoffmann HH, Carrasco SE, Rice CM, Tavazoie SF. Common human genetic variants of APOE impact murine COVID-19 mortality. Nature. 2022 Nov;611(7935):346-351. doi: 10.1038/s41586-022-05344-2. Epub 2022 Sep 21. PMID: 36130725; PMCID: PMC10957240.
Liu X, Mei W, Padmanaban V, Alwaseem H, Molina H, Passarelli MC, Tavora B, Tavazoie SF. A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs. Mol Cell. 2022 Jul 21;82(14):2604-2617.e8. doi: 10.1016/j.molcel.2022.05.008. Epub 2022 Jun 1. PMID: 35654044; PMCID: PMC9444141.
Moy RH, Nguyen A, Loo JM, Yamaguchi N, Kajba CM, Santhanam B, Ostendorf BN, Wu YG, Tavazoie S, Tavazoie SF. Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization. Dev Cell. 2022 May 9;57(9):1146-1159.e7. doi: 10.1016/j.devcel.2022.04.010. Epub 2022 Apr 28. PMID: 35487218; PMCID: PMC9446818.
Passarelli MC, Pinzaru AM, Asgharian H, Liberti MV, Heissel S, Molina H, Goodarzi H, Tavazoie SF. Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics. Nat Cell Biol. 2022 Mar;24(3):307-315. doi: 10.1038/s41556-022-00856-5. Epub 2022 Mar 14. PMID: 35288656; PMCID: PMC8977047.
Kurth I, Yamaguchi N, Andreu-Agullo C, Tian HS, Sridhar S, Takeda S, Gonsalves FC, Loo JM, Barlas A, Manova-Todorova K, Busby R, Bendell JC, Strauss J, Fakih M, McRee AJ, Hendifar AE, Rosen LS, Cercek A, Wasserman R, Szarek M, Spector SL, Raza S, Tavazoie MF, Tavazoie SF. Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels. Sci Adv. 2021 Oct 8;7(41):eabi7511. doi: 10.1126/sciadv.abi7511. Epub 2021 Oct 6. PMID: 34613776; PMCID: PMC8494442.
Huh D, Passarelli MC, Gao J, Dusmatova SN, Goin C, Fish L, Pinzaru AM, Molina H, Ren Z, McMillan EA, Asgharian H, Goodarzi H, Tavazoie SF. A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression. EMBO J. 2021 Jan 15;40(2):e106696. doi: 10.15252/embj.2020106696. Epub 2020 Dec 21. PMID: 33346941; PMCID: PMC7809793.
Tavora B, Mederer T, Wessel KJ, Ruffing S, Sadjadi M, Missmahl M, Ostendorf BN, Liu X, Kim JY, Olsen O, Welm AL, Goodarzi H, Tavazoie SF. Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis. Nature. 2020 Oct;586(7828):299-304. doi: 10.1038/s41586-020-2774-y. Epub 2020 Sep 30. PMID: 32999457; PMCID: PMC8088828.
Ostendorf BN, Bilanovic J, Adaku N, Tafreshian KN, Tavora B, Vaughan RD, Tavazoie SF. Common germline variants of the human APOE gene modulate melanoma progression and survival. Nat Med. 2020 Jul;26(7):1048-1053. doi: 10.1038/s41591-020-0879-3. Epub 2020 May 25. PMID: 32451497; PMCID: PMC8058866.
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